Sure, I made a live-codable audio plugin (VST) that runs Lua/LuaJIT. From my experience, the only thing that slows it down is the fact that it uses double floats which are unnecessarily precise. The JIT and memory management are very efficient, especially following some of Mike Pall's recommendations such as scoping all variables to be as short-lived as possible (eg. using do...end blocks to explicitly define scope).

I haven't had the time to work on it in a while but it works: https://github.com/pac-dev/protoplug