Beyond all the fraud, lying, and deceit, the real shame is the lost opportunity and the associated colossal mismanagement. Theranos was able to marshal about a billion dollars with an overarching goal of democratizing access to health data. They basically accomplished nothing. Generating such a concentration of resources for this goal was a notable accomplishment. The subsequent arrogant (and stupid) inability to discern "hard" from "impossible" and adjust their approach to maintain some chance of success to the overarching goal was a grotesque and massive failure.