Wine won't work with a lot of the enterprisy stuff that also requires license servers, etc.

Besides the design stuff, the entire manufacturing industry is dependent on Microsoft. There are thousands -- probably hundreds of thousands -- of air-gapped NT4 machines in factories running very specific but unsupported for 20 years software, for example. All the big MES systems, test software, and various tooling to run factories are all designed for Windows only.

This is correct.

Some of that software, especially for controlling specific hardware, can even be DOS software.

The hardware can be reliable and expensive; software support, long unavailable.

Wish it worked with SolidWorks. Their compatibility page for that application is mostly "Garbage" rankings.