For me the element blockers are the most important of all. It's not just about blocking ads. It's about making websites more usable. Ads are only one of those detrimental points. Many websites bombard you with big photos of their articles. I block all that with custom blocklists so the end result is a lot more like here at hacker news.
The main difference between this and current element blockers is that Web Defuser allows you to block annoying behaviors (by modifying requests/responses in flight) in addition to elements.
At the moment it's a bit lacking in the UI department, I'd appreciate early adopter feedback (you can contact me at gmail with my username).
The webRequestBlocking api, which allows the extension to inspect all request/responses in real time and act on them. With manifest v3 the extension can only supply a list of expressions to block, and the expressions that can be used is very limited.