Not really in the conventional way people think of hallucinations.
What you see is distorted, but everything you see is actually there. The walls might look like they're dripping or wavy, the branches on a tree appear to reach out at you, and colors become more vibrant, but you won't ever see gigantic bunnies or flying unicorns or some other stupid shit that often ends up in film depictions of a psychedelic experience.
As dosage increases, your mind increasingly tends to interpret what you're seeing as something else, like a shadow may appear briefly to be a person. When this starts to happen I would no longer feel comfortable driving, but for me this occurs at the peak of 500 ug + experiences, the equivalent of 5 standard doses. Not saying that driving on LSD is a great idea, but on a single standard dose it's not nearly as dangerous as driving after you've pulled an all-nighter IMO.
As a human, you are more able to handle hallucinations than you think. If you see a bear off in the distance, in real life do you freak out and drive off the road? No. You just remark at it. "Holy shit a bear in the distance!"
When you're on acid, you don't change as a person, your reactions don't change. If you see something weird you say "woah, that's weird" but, unless you're deep in a trip and forget you are on a substance, you can usually handle it like a normal person.
In my experience, one dose of acid will make you see things, but not things that aren't there. More like interesting patterns in clouds. You can clearly distinguish what's real and what's not. That being said, I'd rather not drive, but could imagine doing so.
